Singapore-born and Melbourne-based, Dr. Prash Puspanathan is a modern polymath whose career defies conventional boundaries. Describing himself as a facilitator of others’ success, Puspanathan navigates multiple worlds with ease: clinician, researcher, entrepreneur, advisor, and investor.
Puspanathan first made his mark in finance with Caleb & Brown, the personalised cryptocurrency brokerage he co-founded in 2016. Under his leadership, the firm grew into a global player, serving over 29,000 clients in more than 100 countries. It also offered a 24/7 personal broker model that brought trust and accessibility to an often chaotic market. Recognised with awards such as Fintech Startup of the Year and Young Executive of the Year, Caleb & Brown bridged traditional financial expertise and the emerging digital asset economy — a gap Puspanathan had long identified growing up amid Singapore’s private banking circles. In 2025, the company was acquired by Swyftx in Australia’s largest crypto acquisition to date, a milestone that capped a chapter of transformative innovation.
Yet finance is only one of Prash Puspanathan’s dual pursuits. A clinician at heart, he co-founded Enosis Therapeutics to explore the intersection of technology and mental health. The company’s Spatial Therapeutics (STx) framework combines virtual reality with psychedelic-assisted therapy to create structured, measurable interventions. The method earned an Australian Innovation Patent. Puspanathan’s work extends beyond therapy rooms: he actively supports early-stage ventures in psychedelics, advocating for ethical investment and evidence-driven approaches while challenging stigma.
Across every field, Puspanathan pursues a single principle: meaningful impact. “Wealth functions as potential energy,” he explains, “its value only emerges when converted into tangible work — systemic change, cultural momentum, or measurable human benefit.” From shaping the future of finance to redefining the landscape of mental health, he continues to chart unconventional paths, demonstrating that innovation is as much about vision as it is about connecting the dots others fail to see.
